Idiopathic Limbal Squamous Metaplasia

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Idiopathic limbal squamous metaplasia.

Squamous metaplasia is an abnormal epithelial differentiation represented on the ocular surface by a spectrum of skin-like changes of conjunctival and corneal epithelium. This pathologic condition can be observed in a variety of ocular surface disorders, including systemic vitamin A deficiency and cicatricial keratoconjunctivitis. We recently encountered a patient with a progressively enlarging...

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Air exposure induced squamous metaplasia of human limbal epithelium.

PURPOSE Squamous metaplasia is a pathologic process that frequently occurs in nonkeratinized stratified ocular surface epithelia. The mechanism for this occurrence is largely unknown except for vitamin A deficiency. METHODS Human limbal explants were cultured under airlift with or without p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 or in a submerged manner for different dur...

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[Corneal epithelium squamous metaplasia determination as diagnostic factor in limbal deficiency].

PURPOSE To determine the correlation between the squamous metaplasia grade of the corneal surface and the clinical severity of the limbal deficiency in patients with this disorder. METHODS We studied 98 eyes of patients with limbal deficiency by impression cytology. These patients were divided into four groups in relation to their clinical severity: 14 eyes had no symptoms, 34 eyes showed a m...

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Squamous metaplasia without atypia.

An 89-year-old man presented with a 1-month history of anemia. The results of a physical examination were normal. Diagnostic gastrointestinal endoscopy showed advanced atrophic gastritis, multiple ulcer scars, and a whitish, slightly depressed lesion 15mm in size in the lesser curvature of the antrum (●" Fig.1). Squamous metaplasia without atypia was diagnosed based on examination of the specim...

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ژورنال

عنوان ژورنال: Archives of Ophthalmology

سال: 2003

ISSN: 0003-9950

DOI: 10.1001/archopht.121.10.1473